Pantheon’s passive is the “Immortal Will”, which ensures that after 5 autoattacks or abilities, the next ability is boosted. Using this boost for the right ability depending on the situation is important if you want to master Pantheon.

You start the game with Pantheon’s Q, the “Comet Spear”. You can use this ability in 2 different ways. If you tap the Q briefly, Pantheon will thrust his spear in the selected direction and deal physical damage to all enemies hit. This reduces the Q’s cooldown by 60% so that you can use it again more quickly. This means that you can deal a fair amount of DPS by repeatedly using the Q with just a tap. The second option is to hold down the Q. As soon as you release the button, Pantheon throws his spear and deals full damage to the first enemy hit and half damage to all other enemies hit. This gives you more range and allows you to finish off fleeing targets before they can escape. Both variants of Q also critically hit enemies below 20% health and deal slightly more than double damage in this case. If you use a Q boosted by your passive, it will also receive bonus damage. As your main source of damage and only waveclear, maximize Q first.

At level 2 you put a point into your W for the first time, the “Shield Jump”. This is a point & click ability which, when activated, causes Pantheon to jump onto the selected target, stunning them for 1 second and dealing physical damage. If you use a boosted W, Pantheon will hit 3 times with his next autoattack and deal additional damage. The W is your only CC, so make sure you use it on worthwhile targets. You maximize the W as your last ability, as the Q’s damage and the E’s survivability are more important to you.

At level 3, you take your E, Aegis Onslaught, as your last base ability. When activated, Pantheon rams his shield into the ground and becomes immune to frontal damage for 1.5 seconds, during which time he thrusts his spear several times, dealing physical damage to all enemies hit. At the end of the ability, Pantheon strikes with his shield, again dealing increased damage. The E can be reactivated to end it early and use the shield strike for additional burst. With a boosted E, Pantheon also gains 60% additional movement speed for 1.5 seconds at the end. You can use this to chase your opponent afterwards or to retreat. The E is your only defensive ability that you mostly use to block enemy damage and is therefore maximized as a second basic ability.

Pantheon’s ultimate ability, Astral Collision Course, is leveled at level 6, 11 and 16. It passively increases your armor penetration by a percentage. When you activate the ult, Pantheon leaps into the air and throws his spear at the selected target location, dealing physical damage to nearby enemies and slowing them by 50% for 2 seconds. Pantheon then flies to the target location as a comet and deals massive magic damage over a larger area. The ult also sets your passive to maximum stacks so that your next ability is boosted. You use the ult to catch unwary opponents on the sidelanes or to join a teamfight.

Trading combo W->AA->Q->AA->E: for short trades in lane, first stack your passive and then jump on your opponent with the boosted W, followed by the triple autoattack. You then deal even more damage with the tapped Q and another autoattack before activating E and retreating from the trade.

Ult combo R->AA->W->AA->Q->E: if you land directly on your opponent with the Ult, you want to perform an autoattack followed by your W and the triple autoattack. Then, depending on the situation, you can either chase your opponent with Qs and further autoattacks or just tap Q briefly for an additional burst and then activate E directly to block incoming damage.